Download Advances in Medicinal Chemistry: 4 by B. E. Maryanoff,A. B. Reitz PDF

By B. E. Maryanoff,A. B. Reitz

quantity four of Advances in Medicinal Chemistry is constituted of six chapters on a variety of issues in medicinal chemistry, together with molecular modeling, structure-based drug layout, natural synthesis, peptide conformational research, organic evaluate, structure-activity correlation, and lead optimization. bankruptcy 1 provides an account approximately amino acid-based peptide mimetics such as b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. bankruptcy 2 addresses new points of the medicinal chemistry of the $64000 anticancer drug Taxol® (paclitaxel). bankruptcy three relates an account of the hunt for brand new medications for the remedy of malaria in response to the traditional product artemisinin. bankruptcy four applies computational chemistry to the assessment of compound libraries for organic trying out. bankruptcy five describes the development of a third-dimensional molecular version of the human thrombin receptor, the 1st protease-activated G-protein coupled receptor (PAR-1), as a method to discover the intermolecular contacts excited by agonist peptide acceptance. ultimately, bankruptcy 6 describes the examine carried out at Merck on inhibitors of farnesyl transferase as a possible therapy for human cancers.

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